How Not to Study a Disease
By Karl Herrup
By Karl Herrup
By Karl Herrup
By Karl Herrup
By Karl Herrup
By Karl Herrup
Category: Wellness | Science & Technology
Category: Wellness | Science & Technology
Category: Wellness | Science & Technology
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$21.95
Mar 07, 2023 | ISBN 9780262546010
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$27.95
Oct 05, 2021 | ISBN 9780262045902
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Oct 05, 2021 | ISBN 9780262365758
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Praise
“In How Not to Study a Disease, a lucid, knowledgeable, but not entirely objective critique of the field of Alzheimer’s research, Karl Herrup, a professor of neurobiology at the University of Pittsburgh School of Medicine, analyzes this challenge. He describes the complexity of even defining the disease; tells of the excitement of Alzheimer’s research in the 1990s, when its cause was thought to be understood and treatments seemed imminent; and charts the long and expensive trickle of disappointment in the decades since, as it has become clear that the disease is much more complicated than was initially thought. As his title signals, Herrup criticizes the field for its adherence to a causal theory of Alzheimer’s that he argues does not hold up.”
—New York Review of Books
Table Of Contents
Prologue ix
I In the Beginning 1
1 A Layperson’s History of Alzheimer’s Disease 3
2 A Physician’s History of Alzheimer’s Disease 23
3 A Scientist’s History of Alzheimer’s Disease 33
4 Mystery Solved! How Four Discoveries Transformed an Entire Field 53
II What Happened to our Cure? 71
5 Building a Model of Alzheimer’s Disease 73
III Double-Edged Swords 97
6 Federal Support of Basic Biomedical Research 99
7 The Pharmaceutical and Biotech Industry 115
8 Testing Our Models: Breaking Bad 131
9 What is Alzheimer’s Disease? 149
IV Where Shall We Go From Here? 169
10 A Layperson’s Guide to the Biology of Aging 171
11 Building a New Model of Alzheimer’s Disease 187
12 Rebalancing our Research Portfolio 207
13 Rebalancing our Institutions 227
14 Final Thoughts 243
Acknowledgments 247
Notes 249
Index 255
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